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Faculty


John M. Pezzuto

Dean, College of Pharmacy

A.B. Chemistry, Rutgers UniversityPh.D. Biochemistry, University of Medicine and Dentistry of New Jersey

Description

Dr. John Pezzuto was appointed professor and Dean of LIU Pharmacy in 2015. Prior to joining the College, Dr. Pezzuto served as dean of the College of Pharmacy, Nursing, and Health Sciences at Purdue University in Indiana, and served as the founding dean of the Daniel K. Inouye College of Pharmacy at the University of Hawaii at Hilo. Dr. Pezzuto has served as an administrator and researcher in academic pharmacy for more than 30 years.

Dr. Pezzuto was the 2014 recipient of the Volwiler Research Award by the American Association of Colleges of Pharmacy. His current research interests are predominantly in the areas of biology-driven natural product drug discovery and characterization, with primary emphasis in the fields of cancer chemotherapy and cancer chemoprevention. He is widely known for identifying the cancer-prevention aspects of resveratrol, a chemical found in grapes and grape products.

Dr. Pezzuto has directed the research of numerous doctoral students, postdoctoral associates, and visiting scholars, and is the recipient of various awards, including being elected Senior University Scholar at University of Illinois at Chicago (UIC) in 1999, UIC Inventor of the Year in 2000, and Fellow of the American Association for the Advancement of Science in 2012.

Dr. Pezzuto is the author of more than 500 publications, co-inventor of several patents, the editor of four books, and a member of over 10 editorial boards of international journals. He is the editor-in-chief of the journal Pharmaceutical Biology.

Specialties

Natural Product Drugs

Research Interests:

  • Discovery and characterization of natural product drugs with emphasis on cancer therapy and prevention; evaluation of grapes and health.

Publications

Choi, Y., Jermihov, K., Nam, S.J., Sturdy, M., Maloney, K., Qiu, X., Chadwick, L.R., Main, M., Chen, S.N., Mesecar, A.D., Farnsworth, N.R., Pauli, G.F., Fenical, W., Pezzuto, J.M., and van Breemen, R.R. , Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS,  Anal. Chem., 83: 1048-1052, 2011.

 Yang, J.H., Kondratyuk, T.P., Jermihov, K.C., Marler, L.E., Qiu, X., Choi, Y., Cao, H., Yu, R., Sturdy, M., Huang, R., Liu, Y., Wang, L.Q., Mesecar, A.D., van Breemen, R.B., Pezzuto, J.M., Fong, H.H., Chen, Y.G., and Zhang, H.J. , Bioactive compounds from the fern Lepisorus contortus,  J. Nat. Prod., 74: 129-136, 2011.

 Pezzuto, J.M., The phenomenon of resveratrol: redefining the virtues of promiscuity, Ann. NY Acad. Sci., 1215: 123-130, 2011.

Zou, J., Pan, L., Li, Q., Zhao, J., Pu, J., Yao, P., Gong, N., Lu, Y., Kondratyuk, T.P., Pezzuto, J.M., Fong, H.H., Zhang, H., and Sun, H., Rubesanolides A and B: Diterpenoids from Isodon rubescens, Org. Lett., 13: 1406-1409, 2011.

Park, E-J, Kondratyuk, T.P., Morrell, A., Kiselev, E., Conda-Sheridan, M., Cushman, M., Ahn, S., Choi, Y., White, J.J., van Breemen, R.B., and Pezzuto, J.M.  , Induction of retinoid X receptor activity and consequent up-regulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells, Cancer Prev. Res., 4: 592-607, 2011.

Park, E.J., Cheenpracha, S., Chang, L.C., Kondratyuk, T.P., and Pezzuto, J.M. , Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy) benzyl]isothiocyanate from Moringa oleifera, Nutr. Cancer, 63: 971-982, 2011.

Kondratyuk, T.P., Park, E.J., Marler, L.E., Ahn, S., Yuan, Y., Choi, Y., Yu, R., van Breemen, R.B., Sun, B., Hoshino, J., Cushman, M., Jermihov, K.C., Mesecar, A.D., Grubbs, C.J., and Pezzuto, J.M.  , Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity, Mol. Nutr. Food Res., 55: 1249-1265, 2011.

Vang, O., Ahmad, N., Baile, C.A., Baur, J.A., Brown, K., Csiszar, A., Das, D.K., Delmas, D., Gottfried, C., Lin, H.Y., Ma, Q.Y., Mukhopadhyay, P., Nalini, N., Pezzuto, J.M., Richard, T., Shukla, Y., Surh, Y.J., Szekeres, T., Szkudelski, T., Walle, T., and Wu, J.M. , What is new for an old molecule? Systematic review and recommendations on the use of resveratrol, PLoS One, 6: e19881, 2011.

Luqman, S., Meena, A., Marler, L.E., Kondratyuk, T.P., and Pezzuto, J.M., Suppression

of tumor necrosis factor-α-induced nuclear factor κB activation and aromatase activity by capsaicin and its analog capsazepine,  J. Med. Food, 14: 1344-1351, 2011.

Park, E.J., Kiselev, E., Conda-Sheridan, M., Cushman, M., and Pezzuto, J.M. , Induction of apoptosis by 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via modulation of MAPKs (p38 and c-Jun N-terminal kinase) and c-Myc in HL-60 human leukemia cells,  J. Nat. Prod. 75: 378-384, 2012.

Park, E.J., Cheenpracha, S., Chang, L.C., and Pezzuto, J.M., Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/IκB/NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells, Phytochem. Lett., 4: 426-431, 2011.

Shen, L., Park, E.J., Kondratyuk, T.P., Guendisch, D., Marler, L., Pezzuto, J.M., Wright, A.D., and Sun, D. , Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents,  Bioorg. Med. Chem., 19: 6182-6195, 2011.

Mayhoub, A.S., Marler, L., Kondratyuk, T.P., Park, E.J., Pezzuto, J.M., and Cushman, M., Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets, Bioorg. Med. Chem. 20: 510-520, 2012.

Guilford, J.M. and Pezzuto, J.M., Wine and health: A review, Am. J. Enol. Vitic. 62: 471-486, 2011.

Guilford, J.M. and Pezzuto, J.M., Cancer Chemoprevention, in Phytochemistry and Pharmacognosy, Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford, UK, (2011). [http://www.eolss.net]

Kato, M.J. and Pezzuto, J.M., edited by M.J. Kato and J.M. Pezzuto, in, Phytochemistry and Pharmacognosy, in Phytochemistry and Pharmacognosy, Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford, UK, (2011).  [http://www.eolss.net]

Kondratyuk, T.P., Park, E.-J., Yu, R., van Breemen, R.B.,  Asolkar, R.N., Murphy, B.T., Fenical, W., and Pezzuto, J.M.  , Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents, Mar. Drugs 2012, 10(2), 451-464; doi: 10.3390/md10020451.

Mayhoub, A.S., Marler, L., Kondratyuk, T.P., Park, E.-J., Pezzuto, J.M., and Cushman, M., Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol, Bioorg. Med. Chem., 20: 2427-2434, 2012.

Park, E.-J., Pezzuto, J.M., Jang, K.W., Nam, S.-J., Bucarey, S.A., and Fenical, W. Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells, Nat. Prod. Commun. 6: 789-794, 2012.

Park, E-J and Pezzuto, J.M., Flavonoids in cancer prevention, Anti-Cancer Agents Med. Chem., 12: 836-851, 2012.

Chen, L., Conda-Sheridan, M., Reddy, P.V.N., Morrell, A., Park, E.-J., Kondratyuk, T.P., Pezzuto, J.M., van Breemen, R.B., and Cushman, M. , Identification, Synthesis, and Biological evaluation of the metabolites of 3-amino-6-(3′-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6−36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents,  J. Med. Chem., 55: 5965-5981, 2012.

Youn, U.J., Park, E.-J., Kondratyuk, T.P., Simmons, C.J., Borris, R.P., Tanamatayarat, P., Wongwiwatthananukit, S., Toyama, O., Songsak, T., Pezzuto, J.M., and Chang, L.C. Anti-inflammatory sesquiterpene lactones from the flowers of Vernonia cinerea, Bioorg. Med. Chem. Lett. 22: 5559-5562, 2012.

Kondratyuk, T.P. and Pezzuto, J.M., Chemistry and biological activity of grapes, in Nutraceuticals and Functional Foods, Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford, UK, (2012) [http://www.eolss.net]

Archer, C.R., Groll, M., Stein, M.L., Schellenberg, B. Clerc, J., Kaiser, M., Kondratyuk, T.P., Pezzuto, J.M., Dudler, R., and Bachmann, A.S. , Activity enhancement of the synthetic syrbactin proteasome 2 inhibitor hybrid and biological evaluation in tumor cells, Biochemistry, 51: 6880-6888, 2012.

Yu, X., Park, E.-J., Kondratuk, T.P., Pezzuto, J.M., and Sun, D., Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NFκB inhibitors, Org. Biomol. Chem. 10: 8835-8847, 2012.

Carlson, S., Marler, L., Nam, S.J., Santarsiero, B.D. Pezzuto, J.M., and Murphy, B.T. , Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.,  Marine Drugs 2013, 11(4), 1152-1161; doi:10.3390/md11041152.

Mayhoub, A.S., Marler, L., Kondratyuk, T.P., Park, E.-J., Pezzuto, J.M., and Cushman, M., Optimizing thiadiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1), Bioorg. Med. Chem. 20: 7030-7039, 2012.

Luqman, S., Meena, A., Singh, P., Kondratyuk, T.P., Marler, L.E., Pezzuto, J.M., Negi. A.S., Neoflavonoids and tetrahydroquinolones as possible cancer chemopreventive agents, Chem. Biol. Drug Des. 80: 616-624, 2012.

Sun, D., Hurdle, J.G., Lee, R.E., Lee, R.E., Cushman, M., Pezzuto, J.M., Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead, Chem. Med. Chem. 7: 1541-1545, 2012.

Chen, L., Conda-Sheridan, M., Reddy, P.V., Morrell, A., Park, E.-J., Kondratyuk, T.P., Pezzuto, J.M., van Breemen, R.B., and Cushman, M. , Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents,  J. Med. Chem.

55: 5965-5981, 2012.

Ihsan-ul-Haq, Mirza, B., Kondratyuk, T.P., Park, E.-J., Burns, B.E., Marler, L.E., and Pezzuto, J.M. ., Preliminary evaluation of the cancer chemopreventive and  cytotoxic potential of naturally growing ethnobotanically selected plants from Pakistan, Pharm. Biol., 51:316-328, 2013

 Conda-Sheridan, M., Park, E.-J., Beck, D.E., Reddy, P.V.N., Nguyen, T.X., Hu, B., Chen, L., White, J.J., van Breemen, R.B., Pezzuto, J.M., and Cushman, M.,  Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential, J. Med. Chem. 56: 2581-2605, 2013.

Park, E.-J. and Pezzuto, J.M , Antioxidant marine products in cancer chemoprevention, Antiox. Redox. Signaling 19: 115-138: 2013 (forum issue on “Antioxidants in Cancer Prevention”).

Ogas, T., Kondratyuk, T.P., and Pezzuto, J.M., Resveratrol analogs: promising chemopreventive agents, Annals NY Acad. Sci. 1290: 21-29, 2013.

Pezzuto, J.M., Kondratyuk, T.P., and Olgas, T, Resveratrol derivatives: A patent review (2009-2012), Expert Opinion Therapeutic Patents 23: 1529-1546, 2013.

Andreani, A., Leoni, A., Locatelli, A., Morigi, R., Rambaldi, M., Cervellati, R., Greco, E., Kondratyuk, T.P., Park, E.-J., Huang, K., van Breemen, R.B., and Pezzuto, J.M, Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles,  Eur. J. Med. Chem., 68: 412-421, 2013.

Pansanit, A., Park, E.-J., Kondratyuk, T.P., Pezzuto, J.M., Lirdprapamongkol, K., and Prasat Kittakoop, P. Vermelhotin, An anti-inflammatory agent, suppresses nitric oxide production in RAW 264.7 cells via p38 inhibition, J. Nat. Prod., 76: 1824-1827, 2013.

Endringer, D.C., Taveira, F.S.N., Kondratyuk, T.P., Pezzuto, J.M., and Braga, F.C., Cancer chemoprevention activity of labdane diterpenes from rhizomes of Hedychium coronarium, Rev. Bras. Farmacogn. 24: 408-412, 2014.

Pan, W., Liu, K., Guan, Y., Tan, G.T., Hung, N.V., Cuong, N.M., Soejarto, D.D., Pezzuto, J.M., Fong, H.H.S., and Zhang, H. , Bioactive Compounds from Vitex leptobotrys, J. Nat. Prod., 77(3):663-667, 2014.

Park, E.-J., Shen, L., Sun, D. and Pezzuto, J.M., Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells, J. Nat. Prod., 77(3):527-535. 2014.

Andreani, A., Leoni, A., Locatelli, A., Morigi, R., Rambaldi, M., Cervellati, R., Greco, E., Kondratyuk, T.P., Park, E.-J., Huang, K., van Breemen, R.B., and Pezzuto, J.M. , Antiproliferative and quinone reductase-inducing activities of withanolides derivatives , Eur. J. Med. Chem., 82:68-81, 2014.

Parrish, S., Yoshida, W., Kondratyuk, T. P., Park, E.-J., Pezzuto, J.M., Kelly, M., and

Williams, P. , Spongiapyridine and related spongians isolated from an Indonesian Spongia sp., J. Nat. Prod., 77:1644-1649, 2014.

Pezzuto, J.M. and Pezzuto, M.F., Academic pharmacy strikes Hawaii (Part 1), Hawaii J. Med. Public Health 74: 33-36, 2015.

Pezzuto, J.M. and Ma, C.S.J., Academic pharmacy strikes Hawaii (Part 2), Hawaii J. Med. Public Health 74: 120-128, 2015.

Park, E.-J and Pezzuto, J.M., The pharmacology of resveratrol in animals and humans, Biochim Biophys Acta, 1852: 1071-1113, 2015.

Jabeen, F., Panda, S.S., Kondratyuk, T.P., Park, E.J., Pezzuto, J.M., Ihsan-UL-Haq, Hall, C.D., Katritzky, A.R. , Synthesis, molecular docking and anticancer studies of peptides and iso-peptides,  Bioorg. Med. Chem. Lett. 25: 2980-2984, 2015.

Hussain, R.A., Badshah, A., Pezzuto, J.M., Ahmed, N., Kondratyuk, T.P., Park, E.J., Ferrocene incorporated selenoureas as anticancer agents, J. Photochem. Photobiol. B 148:197-208, 2015.

Chelsky, Z., Kondratyuk, T.P., Pezzuto, J.M., Cushman, M. and Turkson, J. , A resveratrol analogue promotes ERKMAPK-dependent Stat3 serine and tyrosine phosphorylation alterations and antitumor effects in vitro against human tumor cells,  J. Mol. Pharmacol. 88: 524-533, 2015.

Cragg, G.M and Pezzuto, J.M., Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents, Med. Principles Pract., in press.

Youn,U.J., Sripisut, T., Park, E.J., Kondratyuk, T.P., Fatima,  N., Simmons, C.J., Wall, M.S., Sun, D., Pezzuto, J.M., and Chang, L.C., Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum, Bioorg. Med. Chem. Lett., 25: 4719-4723, 2015.

Other Publications

Suh, N. and Pezzuto, J.M. Strawberry Fields Forever? Cancer Prev Res; 5; 30–33, 2012 (Perspective).

Suh, N. and Pezzuto, J.M. Preface. Topics in Current Chemistry. Vol. 329. Natural Products in Cancer Prevention and Therapy. J.M Pezzuto and N. Suh (Eds.), pp. v-vii, Springer, New York / Heidelberg, 2013.

Vang, O. and Pezzuto, J,M. Introduction to Resveratrol and Health: 3rd International Conference. Ann. N. Y. Acad. Sci. 1348: v-vi doi, 2015.

Pezzuto, J.M. Preface for Grapes and Health. J.M. Pezzuto (Ed.), Springer-Verlag GmbH, Heidelberger, will be published in 2016.

Phytochemistry and Pharmacognosy, edited by M.J. Kato and J.M. Pezzuto, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford, UK [http://www.eolss.net] (2011).

Topics in Current Chemistry. Vol. 329. Natural Products in Cancer Prevention and Therapy. J.M Pezzuto and N. Suh (Eds.), pp. 257, Springer, New York / Heidelberg, 2013.
Grapes and Health. J.M. Pezzuto (Ed.), Springer-Verlag GmbH, Heidelberger, will be published in 2016.

Lectures and Presentations

Shen, L., Park, E.-J., Kondratyuk, T.P., Guendisch, D., Marler, L., Pezzuto, J.M., Wright, A.D., and Sun, D., Synthesis of callophycin A analogues and evaluation as potential chemopreventive and anticancer agents. , 241st American Chemical Society National Meeting, Anaheim, CA , March 27-31, 2011.

 Chen, L., Cushman M., Pezzuto, J.M., and van Breemen, R.B. , Human metabolism of AM6-36, a retinoid X receptor-alpha ligand, , American Chemical Society National Meeting, Denver, Colorado , June 5-9, 2011.

Pezzuto, J.M., Cushman, M., Fenical, W., Mesecar, A., and van Breemen, R.B.  , The role of natural products in cancer chemoprevention., 2nd Annual Conference of the American Council for Medicinally Active Plants, Huntsville, Alabama, July 17, 2011.

Fatima, N., Ahmed, S., Kondratyuk, T.P., Park, E.J., Marler, L.E., Youn, U.J., Qazi, M.A., Pezzuto, J.M., Chang, L.C.  , Cancer chemopreventive potential of endophytic fungi isolated from Taxus baccata. 52nd Annual Meeting of the American Society of Pharmacognosy.  San Diego, CA, July 30-August 3, 2011.

Ul-Haq, I., Youn, U.J., Park, E.J., Kondratyuk, T.P., Marler, L.E., Mirza, B., Pezzuto, J.M., and Chang, L.C.  , Biologically active withanolides from Withania coagulans, 52nd Annual Meeting of the American Society of Pharmacognosy.  San Diego, CA, July 30-August 3, 2011.

Pezzuto, J.M., The promise of resveratrol.  , Recent Advances in the Chemistry of Natural Products, University of São Paulo at São Carlos, Brazil, October 28, 2011.

 Pezzuto, J.M., Cushman, M., Fenical, W., Mesecar, A. and van Breemen, R.B. ,  The challenges and promise of cancer chemoprevention: The role of natural products ,  3rd Brazilian Conference on Natural Products (BCNP), Ouro Preto, MG, Brazil,  October 29-November 2, 2011.
Pezzuto, J.M., The phenomena of resveratrol. , 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Marler, L.Mayhoub, A., Cushman, M., and Pezzuto, J.M.  , Thiadiazole and thiadiazole Derivatives of resveratrol as inducers of quinone reductase 1. , 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Luqman, S., Kondratyuk, T.P., Hoshino, J., Cushman, M., and Pezzuto, J.M. , Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylate activity by resveratrol derivatives., 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Park, E.J., Cheenpracha, S., Chang, L.C., Kondratyuk, T.P., and Pezzuto, J.M. , Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2α-O-acetyl-α-L-rhamnosyloxy)benzyl] isothiocyanate in LPS-stimulated raw 264.7

cells., 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Kondratyuk, T.P., Park, E.J., Hirokawa, T., Leong, E., Cushman, M., and Pezzuto, J.M., Resveratrol derivative (E)-4-(3, 5-dimethoxystyryl) aniline is a novel inhibitor of cancer cell invasion. , 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Park, E.J, Shen, L., Sun, D., Kondratyuk, T.P., and Pezzuto, J.M., Inhibitory effect of a callophycin A derivative on iNOS expression in lipopolysaccharide-stimulated RAW 264.7 cells, 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Park, E.J., Cheenpracha, S., Chang, L.C., Kondratyuk, T.P., and Pezzuto, J.M., Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase by epimuqubilin a in RAW 264.7 cells. , 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Youn, U.J., Park, E.J., Kondratyuk, T.P., Toyama, O., Songsak, T., Wongwiwatthananukit, S., Pezzuto, J.M., and Chang, L.C, Biologically active constitutes from the flower of Vernonia cinerea. , 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Mayhoub, A.S., Marler, L., Kondratyuk, T.P., Park, E.-J., Pezzuto, J.M., and Cushman, M., Optimization of thiazole analogues of resveratrol for induction of quinone reductase 1 (QR1), 243rd ACS National Meeting & Exposition, San Diego, CA, March 25-29, 2012.

Park, E.-J., Morrell, A., Conda-Sheridan. M., Cushman, M., and Pezzuto, J.M. , Characterization of the anti-proliferative effect of 6-(3-aminopropyl)-9-methoxy-3-nitro-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione in cultured PC-3 cells.,  Annual Meeting of the American Association for Cancer Research, Chicago, IL., March 31-April 4, 2012.

Pezzuto, J.M. The Extraordinary Life of a Simple Stilbene: Resveratrol. 13th Congress of the International Society for Ethnopharmacology, Graz, Austria, Sept. 2-6, 2012.

Pezzuto, J.M., Resveratrol and clinical development. , 27ème Seminare en Sciences Pharmaceutiques Programme Doctoral en Sciences Pharmaceutiques, Drugs from Nature: from Discovery to Clinic, Zermatt, Switzerland, Sept. 3-7, 2012.

Pezzuto, J.M. and Park, E.-J. , Cancer prevention, 27ème Seminare en Sciences Pharmaceutiques Programme Doctoral en Sciences Pharmaceutiques, Drugs from Nature: from Discovery to Clinic, Zermatt, Switzerland, Sept. 3-7, 2012.

Pezzuto, J.M., Biological evaluation of resveratrol and derivatives. , Resveratrol 2012, University of Leicester, Leicester, UK, December 5, 2012.

Sang-ngern, M., Youn, U.J., Park, E.-J., Kondratyuk, T.P., Miklossy, G., Simmons, C.J., Turkson, J., Pezzuto, J.M., and Chang, L.C. , Anticancer potential of Physalis peruviana (poha), Annual meeting of the American Society of Pharmacognosy, St. Louis, MO., July 14-17, 2013.

Pezzuto, J.M., The promise and challenges of cancer chemoprevention. , Lecture presented at Shanghai University  and Zhejiang University, PRC., June 9, 2014 and June 10, 2014

Sang-ngern, M., Youn, U.J., Park, E.-J., Kondratyuk, T.P., Miklossy, G., Simmons, C.J., Turkson, J., Pezzuto, J.M., and Chang, L.C. , Evaluation of Physalis peruviana (poha) as anticancer agents.,  Annual meeting of the American Society of Pharmacognosy, July 2014.

Pezzuto, J.M. , Resveratrol: A highly permiscuous molecule leads the way to monogamous interactions., 14th International Congress of Ethnopharmacology ISE 2014, Sociedad Latinoamericana de Fitoquimica SLF, Puerto Varas, Chile, September 23-26, 2014.

Pezzuto, J.M. The remarkable life and times of resveratrol (the “Ohdang Plenary Lecture of 2014), Fall Annual Convention of the Pharmaceutical Society of Korea, Gyeongjy, Korea, October 23-24, 2014.

Yu, X., Park, E.-J, Kondratyuk, T.P., Pezzuto, J.M., and Sun, D., Synthesis and evaluation of 2-arylindole derivatives as anticancer and cancer chemopreventive agents. Reveratrol, 2014 Conference, Big Island, Hawaii, Dec. 2014.

Pezzuto, J.M., Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents. , 5th Kuwait International Pharmacy Conference-2015 (“Kuwait International Pharmacy Conference”), Kuwait City, Kuwait, February 1-3, 2015.

Books/Chapters

  • Pezzuto JM, Park EJ, and Park EJ. Autoxidation and antioxidants, Encyclopedia of Pharmaceutical Science and Technology, 4th Edition (EPST4), edited by J. Swarbrick, 2011.
  • Park, E.-J. and Pezzuto JM. Flavonoids in cancer prevention. Anticancer Agents Med
     Chem. 12: 836-851, 2012.
  • Marler, M. and Pezzuto, J.M. Nutritional phytochemicals and the management of chronic inflammation. In: Inflammation and Cancer: Mechanisms and Dietary Approaches for Cancer Prevention. A.-N. T. Kong (ed.), Taylor & Francis, pp. 585-602, 2013.
  • Cuendet, M., Nievergelt, A. and Pezzuto, J.M. Molecular targets of botanicals used for chemoprevention. In: D.I. Abrams, A.T. Weil (eds.), Integrative Oncology (Second Edition), New York, New York: Oxford University Press, pp. 52-84, 2014.
  • Park, E.-J., Murphy, B.T., and Pezzuto, J.M. Marine organisms in cancer chemoprevention. In: B.J. Baker (ed.), Marine Biomedicine – from Beach to Bedside, CRC Press, in press

Grants/Contracts

Contribution of California Grapes to Longevity and Health, California Table Grape Commission, Jan. 2016-Dec. 2019.

Honors/Awards

NIH Postdoctoral Trainee and Fellow, 1977-1980.

NIH Research Career Development Awardee, 1984-1989.

Research Fellow, Alexander von Humboldt Foundation, 1990-1991.

Editor-in-Chief, Pharmaceutical Biology, 1997-present.

Elected Senior University Scholar, University of Illinois at Chicago, 1999.

Elected University of Illinois at Chicago Inventor of the Year, 2000.

Listed in ISIHighlyCited.com (Current Contents) as one of the most highly cited publishing researchers (includes less than 0.5% of researchers), 2002.

Appointed Distinguished University Professor, University of Illinois at Chicago, 2002.

Received Distinguished Alumnus Award, University of Medicine & Dentistry of New Jersey, May 2003.

Received award acknowledging greatest contribution to community health in 2010, Rotary Club of South Hilo, October 2010.

Elected Fellow of the American Association for the Advancement of Science (AAAS), 2012.

Received recognition as ‘Friend of Pharmacy’ during the 2013 annual meeting of the Hawaii Pharmacists Association, 2013.

Selected as recipient of the Volwiler Research Award by the American Association of Colleges of Pharmacy, 2014.

Selected by the Cantine Due Palme to be honored with its “Premio Speciale Cantine Due Palme” award.  The award is presented by the winery to “eminent personalities who made outstanding contributions in the field of research and culture.” Award presented at a ceremony on May 9, 2014, in the exclusive Selvarossa Conference Room, located in Puglia, Italy.

Selected to present the Ohdang Plenary Lecture of 2014, Fall Annual Convention of the Pharmaceutical Society of Korea, Gyeongjy, Korea, October 2014.

Presented keynote commencement address at the 2015 Graduation Commencement of the University of Hawaii at Hilo (received Chancellor’s Award for Excellence).

Selected as recipient of the 2016 Distinguished Service Award, University of Hawaii at Hilo, Hilo, Hawaii.

Other Professional Activities

  • Member, Scientific Committee, 3rd Brazilian Conference on Natural Products (BCNP), Ouro Preto, MG, Brazil, October 29-November 2, 2011.
  • Member, Scientific and Organizing Committees and Local Host, 50th Annual Meeting of the Phytochemical Society of North America, December 10-15, 2011, Fairmont Orchid, Hawaii.
  • Member, Scientific Committee, Resveratrol 2012, University of Leicester, Leicester, UK, December 5-7, 2012.
  • Member of the Congress Scientific Committee, Sociedad Latinoamericana de Fitoquímica (SLF) and the International Society for Ethnopharmacology (ISP), Puerto Varas, Chile, September, 2014.
  • Member, Scientific and Organizing Committees, Resveratrol 2014, Big Island, Hawaii, December 2014.