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Faculty


Rahul Haware

Associate Professor of Pharmaceutics and Industrial Pharmacy

Ph.D. in Pharmaceutics, University of Tromsø, Tromsø, NorwayM.S. in Molecular Biology, Universty of Skövde, Skövde, Sweden/ University of Heidelberg, Heidelberg, GermanyM.S. in Pharmaceutical Sciences, University of Pune, Pune, India

https://scholar.google.com/citations?user=vWUB-rcAAAAJ&hl=en

Description

I am a 'Pharmaceutical Material Scientist' and my laboratory is investigating the impact of the physico-mechanical properties of the pharmaceutical materials using our developed DM3 approach on the final pharmaceutical dosage form performance during powder flow, mixing, compaction, and physical stability. DM3 approach includes understanding interplay of the molecular and macroscopic properties of materials (M1) and crtical manufacturing parameters (M2) using design of experiments (D) and multivariate analysis (M3). This is important in relation with 'Process Analytical Technology' (PAT) and 'Quality by Design' (QbD) paradigm issued by US FDA. The molecular level understanding includes application of advanced analytical techniques like powder and single crystal X-ray diffraction, differential scanning calorimetry, themogravimetric analysis, Fourier transform infra-red spectroscopy, near infrared spectroscopy and molecular and crystallographic modeling.

I am currently applying this approach to the following broader category research areas:
a) Structure-mechanics relationship of flufenamic acid polymorphs
b) Stability issues of coprocessed excipients
c) Molecular mechanism of Promethazine HCl taste masking with Eudragit® E 100
d) Lubrication efficiency and thermal behavior of the magnesium stearate
e) Superdisintegration mechanism of the crosscarmellose sodium (Ac-Di-Sol®) and sodium starch glycolate (Glycolys®)
f) Compaction properties of modified and pregelatinized starches
g) Roller compaction properties of high functionality excipients

Specialties

1. Molecular and macroscopic level powder characterization using advanced techniques like DSC, TGA, FTIR, and important modules in Material Studio®
2. Compaction simulation
3. Roller compaction
4. Tableting performance evaluation
5. Process analytical spectroscopic techniques:
               Near infrared spectroscopy
               FT-IR spectroscopy
               Raman spectroscopy
6. Normal and spectroscopic data handing by multivariate analysis

Publications

  1. R. V. Haware, B. P. Vinjamuri, T. Joshi, W. C. Stagner, Deciphering Thermal Behavior of Common Lubricating Agent Magnesium Stearate, (2017), in preparation
  2. T. Joshi, A. B. Singaraju, H .S. Shah, K. R. Morris, L .L. Lewis, R. V. Haware, Structure-Mechanics and Compressibility Profile Study of Flufenami acid: Nicotinamide cocrystals, (2017), in preparation
  3. R. V. Haware, B. P. Vinjamuri, M. Gavireddi, V. S. Dave, D. Gupta, M. C. Chougule, W. C. Stagner, Physical Properties and Solubility of Nifedipine-PEG 1450/HPMCAS-HF Dispersions Prepared by Melt Solvent methods, (2017), submitted
  4. V. Dave, H. Shahin, S. R. Youngren-Ortiz, M. B. Chougule, R. V. Haware, Emerging Technologies for the Non-Invasive Characterization of Physical Mechanical Properties of Tablets, (2017), Int. J. Pharm., 532 (1), 299-312
  5. A. Singaraju, K. Nguyen, D. C. Swenson, M. Iyer, R. V. Haware, L. Stevens, Reorganized, Weak C-HO Interactions Directly Modify the Mechanical Properties and Compaction Performance of a Series of Nitrobenzoic Acids (2017), CrystEngComm, 10.1039/C7CE00238F
  6. V. S. Dave, C. Mack, H. Boyce, A. Al-Achi, S. Hoag, R. V. Haware, Lubricant Sensitivity Assessment of SPRESS B®820 by Near Infrared Spectroscopy: A Comparison of Multivariate Methods, (2017), J. Pharm. Sci., 106 (2), 537-545
  7. R. Yang, K. Nam, S. W. Kim, J. Turkson, Y. Zou, Y., Zuo, R. V. Haware, M. B. Chougule, Optimization of Biodegradable Nanocarrier Formulation by Taguchi Method and Standard Least Square Method (2017), Mol. Pharm., 14(1), 252-263
  8. A. Gupte, M. DeHart, W.C. Stagner, R. V. Haware, Comparative Binder Efficiency Modeling of Dry Granulation Binders, (2017), Drug Dev. Ind. Pharm., 43 (4), 574-583
  9. B. P. Vinjamuri, R. V. Haware, W. C. Stagner, Particle Engineering Product Design, Multicriteria Optimization, and Critical Attribute Characterization of Inhalable Ipratropium Bromide Microparticles, (2017), AAPSPharmSciTech, 18(6), 1925-1935
  10. A. Singaraju, K. Nguyen, A. Jain, R. V. Haware, L. Stevens, Aggregate elasticity, crystal structure and tableting performance for p-aminobenzoic acid and a series of its benzoate esters, (2016), Mol. Pharm., 13 (11), 3797-3806
  11. A. Singaraju, M. Iyer, R. V. Haware, L. Stevens, Caffeine Co-Crystal Mechanics Evaluated with a Combined Structural and Spectroscopic Approach, (2016), Crystal Grow. Des., 16(8), 4383-4391
  12. R. Parmar, A. Ghanta, R. V. Haware, P. R. Johnson, W. C. Stagner, Statistical Optimization of an Evaporative Light Scattering (ELSD) Detector for Molten Sucrose Octaacetate and Comparison with UV-Diode Array Detection (DAD) Validation Parameters Using Coupled HPLC UV-DAD/ELSD Specific Stability-Indicating Method (2016), J. Pharm. Sci., 105 (12), 3603-3610
  13. R. V. Haware, V. S. Dave, B. Kakrala, S. Delaney, S. Staton, E. Munson, M. R. Gupta, W. C. Stagner, Vegetable-Derived Magnesium Stearate Functionality Evaluation by DM3 Approach (2016), Eur. J. Pharm. Sci., 89, 115-124
  14. V. Dave, M. Chanda, M. Sayles, M. Popielarczyk, H. Boyce, S. Bompelliwar, K. R. Morris, R. V. Haware, Correlation of Structural and Macroscopic Properties of Starches with their Tabletability Using the SM2 Approach (2015), J. Pharm. Sci., 104 (11), 3870-3882
  15. R. V. Haware, J. P. Kancharla, A.K. Udupa, S. Staton, M. R. Gupta, A. Al-Achi, W. C. Stagner, Effect of Relative Humidity on the Physico-Mechanical Properties of Coprocessed Excipients MicroceLac® 100 by DM3 Approach (2015), Pharm. Res., 32 (11), 3618-3635

Lectures and Presentations

  1. A. Jain, P. Johnson, A. Narang, K. R. Morris, R. V. Haware, A Structure-Mechanics Relationship on Tablet Performnce of Flufenamic Acid Polymorphs, The American Association of Pharmaceutical Sciences Annual Meeting, San Diego, CA, 13th November 2017 to 15th November 2017
  2. N. Patil, A. Jain, S. Staton, R. V. Haware, Compressibility Profiles of Coporocessed Excipients at Different Storage Conditions, The American Association of Pharmaceutical Sciences Annual Meeting, San Diego, CA, 13th November 2017 to 15th November 2017
  3. M. Iyer, S. Staton, R. V. Haware, Taste Masking of Isoniazid by Spray Drying, The American Association of Pharmaceutical Sciences Annual Meeting, San Diego, CA, 13th November 2017 to 15th November 2017
  4. T. Joshi, A. B. Singaraju, H .S. Shah, K. R. Morris, L .L. Lewis, R. V. Haware, Structure-Mechanics and Compressibility Profile Study of Flufenamic acid: Nicotinamide cocrystals, (2017), Annual ISPE Meeting, San Diego, CA, 29th October 2017 to 1st November, 2017
  5. V. S. Dave, C. Mack, H. Boyce, A. Al-Achi, S. Hoag, R. V. Haware, Lubricant Sensitivity Assessment of SPRESS B®820 by Near Infrared Spectroscopy: A Comparison of Multivariate Methods, The American Association of Pharmaceutical Sciences Annual Meeting, Denver, Colorado, 11th November 2016 to 17th November 2016
  6. S. K. Bompelliwar, V. B. Vinjamuri, P. R. Johnson, S. Staton, W. C. Stagner, R. V. Haware*, Molecular Level Comparison and Stabilization of Promethazine Hydrochloride and Eudragit® EPO Complex, The American Association of Pharmaceutical Sciences Annual Meeting, Orlando, Florida, 25th October 2015 to 29th October 2015

Honors/Awards

2014 Honarary lifetime member of The Rho Chi Society (The Academic Honor Society in Pharmacy)

2013 Best Poster Presentation Award: Distinction of Powder and Compression Properties of Various Grades and Brands of Microcrystalline Celluloses by Heckel Equation and Multivariate Methods
Conference
: Compaction Simulation Forum, Cambridge, UK

2011 Nominated for ‘Best-Post Doctoral Research Award’: Anisotropic crystal deformation measurements determined using powder X-ray diffraction and a new in situ compression stage
Conference: AAPS conference, Washington DC

2005-2009 Norwegian Research Council scholarship for graduate studies

2002-2004 Graduate Aptitude Test in Engineering (GATE) scholarship by All India Council of Technical Education (AICTE), New-Delhi