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Faculty


Jaclyn Novatt

Assistant Professor of Pharmacy Practice

Ph.D., Biomedical Sciences, The Rockefeller University, New York, NYM.S., Chemistry, Brandeis University, Waltham, MAB.A., Chemistry, Brandeis University, Waltham, MA

Description

Dr. Novatt is a biochemist who is passionate about science and science education.

She was a Howard Hughes Medical Institute pre-doctoral fellow at the Rockefeller University, where she worked with Dr. Michael Rout to study how proteins move in and out of the nucleus of cells. After receiving her Ph.D. in 2009, she moved to Cold Spring Harbor Laboratory where sthe studied the basic mechamisms of RNA splicing and its connection to human disease with Dr. Adrian Krainer. There, she received a postdoctoral training fellowship from the National Cancer Institute.

Since 2008, Dr. Novatt has taught chemistry, biochemistry, genetics, and human biology as an adjunct professor at several colleges and universities throughout the NY metro area.

She came to LIU in January 2017 with the goal of increasing our pharmacy students’ exposure to research. To this end, she has developed a research APPE and two research-based electives – “Introduction to Research” and “From Petri Dish to Pharmacy.” 

In addition to science, Dr. Novatt has a background in theater and improv. She loves working with students to improve their communication skills using improv-based activities.

Specialties

Biochemistry, Molecular biology, Cell biology

Publications

  1. Hough LE, Dutta K, Sparks S, Temel DB, Kamal A, Tetenbaum-Novatt J, Rout MP, Cowburn D. The Molecular Mechanism of Nuclear Transport Revealed by Atomic Scale Measurements. eLife 2015 Sept 15; 4
  2. Tetenbaum-Novatt J, Hough LE, Mironska R, McKenney AS, Rout MP. Nucleocytoplasmic transport: a role for nonspecific competition in karyopherin-nucleoporin interactions. Mol Cell Proteomics 2012 May; 11(5): 31-46
  3. Tetenbaum-Novatt J and Rout MP. The mechanism of nucleocytoplasmic transport through the NPC. Cold Spring Harbor Symp Quant Biol. 2010; 75:567-84.
  4. Jovanovic-Talisman T, Tetenbaum-Novatt J, McKenney AS, Zilman A, Peters R, Rout MP, Chait BT. Artificial nanopores that mimic the transport selectivity of the nuclear pore complex. Nature. 2009 Feb 19; 457(7232): 1023-7
  5. Timney BL, Tetenbaum-Novatt J, Agate DS, Williams R, Zhang W, Chait BT, Rout MP. Simple kinetic relationships and non-specific competition govern nuclear import rates in vivo. J Cell Biol. 2006 Nov 20; 175(4): 579-93
  6. D’Aquino A, Tetenbaum-Novatt J, Ringe D. Mechanism of metal ion activation of the Diphtheria Toxin Repressor DtxR. PNAS USA 2005 Dec 20; 102(51): 18408-13
  7. Strambio-de-Castilla C, Tetenbaum-Novatt J, Imai BS, Chait BT, Rout MP. A Method for the rapid and efficient elution of native affinity-purified Protein A tagged complexes. J Proteome Res. 2005 Nov-Dec; 4(6): 2250-6
  8. Miller LM, Novatt JT, Hammerman D, Carlson CS. Alterations in mineral composition observed in osteoarthritic joints of cynomolgus monkeys. Bone, 2004 Aug; 35(2): 49-506
  9. Tetenbaum J, Miller LM. A new spectroscopic approach to examining the role of disulfide bonds in the structure and unfolding of soybean trypsin inhibitor. Biochemistry, 2001 Oct 9; 40(40): 12215-9

Lectures and Presentations

Invited Talks

  1. Eastern Long Island Mini Maker Faire, Port Jefferson, NY, 2017 “Science Café” – From Petri Dish to Pharmacy, the story of Spinraza
  2. Science Advocacy of Long Island – “Ask a Scientist” Panel, Commack, NY, 2017
  3. Biology, Chemistry, and Environmental Sciences Department, Molly College, Rockville Center, NY, 2014, mRNA splicing – How do our Cells Edit mRNA Properly?
  4. Basic Sciences Department, NYIT, Old Westbury, NY, 2013, Cellular Bouncers – Artificial Nanopores that Mimic the Selectivity of the NPC
  5. Dolan DNA Learning Center, Cold Spring Harbor, NY,     2013, Cellular Bouncers – Artificial Nanopores that Mimic the Selectivity of the NPC
  6. Chemistry Department, York College, CUNY, New York, NY, 2011, Cellular Bouncers – Artificial Nanopores that Mimic the Selectivity of the NPC
  7. Mount Sinai Hospital, New York, NY, 2010, Cellular Bouncers – Artificial Nanopores that Mimic the Selectivity of the NPC
  8. The New School University, New York, NY, 2009, Cellular Bouncers – Artificial Nanopores that Mimic the Selectivity of the NPC

 

Selected Oral Presentations

  1. Anderson Cancer Center Retreat, Tarrytown, NY, 2008 Studying the Nature of Interactions Between Karyopherins, Cargo, and the NPC
  2. HHMI Pre-doctoral Fellows Meeting, Chevy Chase, MD, 2007 Studying the Nature of Interactions Between Karyopherins, Cargo, and the NPC
  3. Anderson Cancer Center Retreat, Tarrytown, NY, 2007 Studying the Nature of Interactions Between Karyopherins, Cargo, and the NPC
  4. NSLS, Brookhaven National Laboratory, Upton, NY, 2001 Alterations in Bone Composition Observed with Age and Osteoarthritis
  5. NSLS, Brookhaven National Laboratory, Upton, NY, 2000 The Role of Disulfide Bonds in the Secondary Structure of Soybean Trypsin Inhibitor

 

Selected Poster Presentations

  1. Long Island University Discovery Day, 2017 Incorporating Student-Centered Learning into Research Advanced Pharmacy Practice Experiences (APPEs)
  2. CSHL Eukaryotic mRNA Processing Meeting, 2015, Cold Spring Harbor, NY Characterization of SMG7 Alternative Splicing in Cancer
  3. 75th Annual Cold Spring Harbor Symposium on Quantitative Biology, 2010   Cold Spring Harbor, NY Studying the Nature of Interactions Between Karyopherins, Cargo, and the NPC
  4. Gordon Research Conference – Protein Transport Across Cellular  Membranes   2007, Il Ciocco, Italy Studying the Nature of Interactions Between Karyopherins, Cargo, and the NPC
  5. Gordon Research Conference – Signal Transduction Within the Nucleus,  2007 Ventura, CA Studying the Nature of Interactions Between Karyopherins, Cargo, and the NPC
  6. Dynamic Organization of Nuclear Function Meeting, 2006 Cold Spring Harbor, NY Studying the Nature of Interactions Between Karyopherins, Cargo, and the NPC
  7. FASEB ASBMB Meeting, 2005, San Diego, CA Studying the Nature of Interactions Between Karyopherins, Cargo, and the NPC

Honors/Awards

2012-2015 National Cancer Institute Postdoctoral Training Fellowship
2003-2008 Howard Hughes Medical Institute Pre-doctoral Fellowship

Professional Affiliations