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Eun-Jung Park

Research Scientist, Cancer Research Laboratories/Dr. Pezzuto LabDirector, Flow Cytometry Core

Ph.D., Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of KoreaM.S., Pharmacy, Ewha Womans University, Seoul, Republic of KoreaB.S., Pharmacy, Ewha Womans University, Seoul, Republic of Korea (Registered pharmacist in Korea)

Description

Dr. Eun-Jung Park earned her Ph.D. in pharmacognosy from Ewha Womans University, with a dissertation entitled “cancer chemopreventive potential of natural product-derived stilbenoids in multistage carcinogenesis”. Dr. Park evaluated the activities of natural products and their analogs on three stages of carcinogenesis, including initiation, promotion and progression, using in vitro cell line based assay. Upon active compounds, Dr. Park studied further to elucidate the molecular mechanisms. She received a Scholar-in-training Award from American Association for Cancer Research (AACR) with her work in 2006. Since then, she is an associate member of AACR. After graduation, Dr. Park joined University of Hawaii as a postdoctoral fellow, and continued her career as a research specialist at the The Daniel K. Inouye College of Pharmacy, University of Hawai’i at Hilo, HI. During this period, she examined the effects of a multitude of samples on nitrite production, aromatase enzymatic activity, free radical production, cancer cell proliferation, transcriptional activity of retinoid X receptor, etc. Various compounds or extracts were found as active, including marine macro- and microorganisms, norsesterterpene peroxides, resveratrol analogs, phenolic glycosides, phenazines, isothiocyanate derivatives, callophycin A analogs, thiadiazole analogs, indenoisoquinolines, sesquiterpene lactones, 2-arylindole derivatives, withanolides, and azaphilones. In 2016, Dr. Park joined College of Pharmacy and Health Sciences, Long Island University as a research scientist. Her current research is focused on the effect of grape-containing diets (regular diet and Western diet) on health and longevity.

Publications

  • Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4β-hydroxywithanolide E isolated from Physalis peruviana. Mol Nutr Food Res. 2016 Jun;60(6):1482-500. http://www.ncbi.nlm.nih.gov/pubmed/27006100
  • Park EJ, Pezzuto JM. The pharmacology of resveratrol in animals and humans. Biochim Biophys Acta. 2015 Jun;1852(6):1071-113. http://www.ncbi.nlm.nih.gov/pubmed/25652123
  • Park EJ, Shen L, Sun D, Pezzuto JM. Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells. J Nat Prod. 2014 Mar 28;77(3):527-35. http://www.ncbi.nlm.nih.gov/pubmed/24299616
  • Park EJ, Pezzuto JM. Antioxidant Marine Products in Cancer Chemoprevention. Antioxid Redox Signal. 2013 Mar 19. 2013 Jul 10;19(2):115-38. http://www.ncbi.nlm.nih.gov/pubmed/23397932
  • Park EJ, Chung HJ, Park HJ, Kim GD, Ahn YH, Lee SK. Suppression of Src/ERK and GSK-3/β-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. Food Chem Toxicol. 2013 May;55:424-33. http://www.ncbi.nlm.nih.gov/pubmed/23333577
  • Park EJ, Park HJ, Chung HJ, Min HY, Hong JY, Kang YJ, Ahn YH, Pyee JH, Lee SK. Antimetastatic activity of pinosylvin, a natural stilbenoid, is associated with the suppression of matrix metalloproteinases. J Nutr Biochem. 2012 Aug;23(8):946-52. http://www.ncbi.nlm.nih.gov/pubmed/21937212
  • Park EJ, Pezzuto JM, Jang KH, Nam SJ, Bucarey SA, Fenical W. Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Nat Prod Commun. 2012 Jun;7(6):789-94. http://www.ncbi.nlm.nih.gov/pubmed/22816309
  • Park EJ, Pezzuto JM. Flavonoids In Cancer Prevention. Anticancer Agents Med Chem. 2012 Oct 1;12(8):836-51. http://www.ncbi.nlm.nih.gov/pubmed/22292763
  • Park EJ, Kiselev E, Conda-Sheridan M, Cushman M, Pezzuto JM. Induction of Apoptosis by 3-Amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via Modulation of MAPKs (p38 and c-Jun N-terminal Kinase) and c-Myc in HL-60 Human Leukemia Cells. J Nat Prod. 2012 Mar 23;75(3):378-84. http://www.ncbi.nlm.nih.gov/pubmed/22148260
  • Park EJ, Cheenpracha S, Chang LC, Pezzuto JM. Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/IκB/NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells. Phytochem Lett. 2011 Dec 1;4(4):426-431. http://www.ncbi.nlm.nih.gov/pubmed/22180763
  • Park EJ, Cheenpracha S, Chang LC, Kondratyuk TP, Pezzuto JM. Inhibition of Lipopolysaccharide-Induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression by 4-[(2'-O-acetyl-α-L-Rhamnosyloxy)Benzyl]Isothiocyanate from Moringa oleifera. Nutr Cancer. 2011 Aug-Sep;63(6):971-82. http://www.ncbi.nlm.nih.gov/pubmed/21774591
  • Park EJ, Min HY, Park HJ, Chung HJ, Ahn YH, Pyee JH, Lee SK. Nuclear Factor E2-Related Factor 2-Mediated Induction of NAD(P)H:Quinone Oxidoreductase 1 by 3,5-Dimethoxy-trans-stilbene. J Pharmacol Sci. 2011;116(1):89-96. http://www.ncbi.nlm.nih.gov/pubmed/21512304
  • Park EJ, Min HY, Chung HJ, Ahn YH, Pyee JH, Lee SK. Pinosylvin Suppresses LPS-stimulated Inducible Nitric Oxide Synthase Expression via the MyD88-independent, but TRIF-dependent Downregulation of IRF-3 Signaling Pathway in Mouse Macrophage Cells. Cell Physiol Biochem. 2011;27(3-4):353-62. http://www.ncbi.nlm.nih.gov/pubmed/21471724
  • Park EJ, Kondratyuk TP, Morrell A, Kiselev E, Conda-Sheridan M, Cushman M, Ahn S, Choi Y, White JJ, van Breemen RB, Pezzuto JM. Induction of Retinoid X Receptor Activity and Consequent Upregulation of p21WAF1/CIP1 by Indenoisoquinolines in MCF7 Cells. Cancer Prev Res (Phila). 2011 Apr;4(4):592-607. http://www.ncbi.nlm.nih.gov/pubmed/21464033
  • Park EJ, Min HY, Chung HJ, Hong JY, Kang YJ, Hung TM, Youn UJ, Kim YS, Bae K, Kang SS, Lee SK. Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells. Cancer Lett. 2009;277(2):133-40. http://www.ncbi.nlm.nih.gov/pubmed/19135778
  • Park EJ, Choi SJ, Kim YC, Lee SH, Park SW, Lee SK. Novel small molecule activators of beta-catenin-mediated signaling pathway: structure-activity relationships of indirubins. Bioorg Med Chem Lett. 2009;19(8):2282-4. http://www.ncbi.nlm.nih.gov/pubmed/19282173
  • Park EJ, Min HY, Ahn YH, Bae CM, Pyee JH, Lee SK. Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells. Bioorg Med Chem Lett. 2004;14(23):5895-8. http://www.ncbi.nlm.nih.gov/pubmed/15501064

Research Synopsis

Grape contains anti-oxidant polyphenols including catechin and resveratrol. The production of reactive oxygen species (ROS) is an inevitable event from aerobic metabolism in mitochondria. ROS might play an important role in aging process via affecting “the hallmarks of aging”, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication (López-Otín et al., Cell, 2013). Therefore, we hypothesized that daily intake of grape, as a polyphenol-rich source, in a regular or a Western diet might attenuate aging process and improve health. To my knowledge, it has not been reported on the systemic and in-depth examination on the effects of lifetime consumption of grape. Hence, we aim to measure various biomarkers and gene expression levels in serum and tissues, periodically.