Dovenia S. Ponnoth, Ph.D.
Assistant Professor, Pharmacology & Toxicology
Ph.D., Pharmaceutical & Pharmacological Sciences, West Virginia University
B.S., Pharmacy, Mumbai University, India
Dr. Dovenia Ponnoth received her Ph.D. degree from West Virginia University. Her postdoctoral experience includes a postdoctoral fellowship in the Department of Physiology & Pharmacology at West Virginia University and prior to that, she received an ORISE fellowship with the National Institute for Occupational Safety and Health. Dr. Dovenia Ponnoth joined the Division of Pharmaceutical Sciences in the fall semester of 2014. Her research and teaching interests include Cardiovascular Pharmacology and Lung Biology. Her main research focus is in Cardiopulmonary Pharmacology and the interaction between reactive airway diseases and the development of cardiovascular diseases (CVD); asthma/COPD pathogenesis; the role of Angiotensin ll and adenosine in lung diseases and CVD. Dr. Ponnoth has presented her work at several international conferences, and serves as a reviewer for many prominent pharmacology journals.
My research focus is lung and vascular pharmacology/physiology. Throughout my research career thus far, I have developed a very strong interest in bridging pulmonary disease and vascular outcomes. Currently, my lab investigates the effects of Angiotensin ll in allergic mice from a cardiopulmonary standpoint in vascular reactivity, vascular and systemic inflammation as well as airway hyperreactivity and airway inflammation in an allergic mouse model of asthma. In studying the effects of Ang ll on inflammation and vascular changes, my research will contribute to a new, less understood area of reactive airway diseases and could potentially add a new dimension to the current knowledge of drug therapy used to manage asthma. My lab makes use of a) whole animals; b) ex vivo and in vitro experiments and c) specific receptor knock-out models to study effects of various agents in vascular/airway relaxation, inflammation and airway resistance. Some of the techniques we use include in-vitro organ bath, whole body plethysmography, airway reactivity, differential inflammatory cell analysis. In addition, we use different proteomic and genomic approaches to study expression and function of specific targets.
- Zaccone, E.J., Thompson, J.A., Ponnoth, D.S., Cumpston, A.M., Goldsmith, W.T., Jackson, M.C., Frazer, D.G., Hubbs, A.F., Shimko, M. and Fedan, J.S. “Popcorn flavoring effects on reactivity of rat airways in vivo and in vitro” J Toxicol Environ Health A. 2013; 76(11):669-89. doi:10.1080/15287394.2013.796302. PMID: 23941636 https://www.ncbi.nlm.nih.gov/pubmed/23941636
- Kunduri S, Mustafa S, Ponnoth D, Dick G, Nayeem M. “Adenosine A1 receptors link to smooth muscle contraction via CYP4a, PKC-α, and ERK1/2.” J Cardiovasc Pharmacol. 2013 Jul; 62(1):78-83. doi: 10.1097/ FJC.0b013e3182919591. PMID: 23519140 https://www.ncbi.nlm.nih.gov/pubmed/23519140
- Ponnoth DS, Nayeem MA, Tilley SL, Ledent C, Mustafa SJ “Cyp-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.” Am J Physiol Regul Integr Comp Physiol. 2012 Nov; 303(10):R1003-10. doi:10.1152/ajpregu.00335.2012. Epub 2012 Sep 26.PMID: 23019210 https://www.ncbi.nlm.nih.gov/pubmed/23019210
- Ponnoth DS, Nayeem MA, Kunduri SS, Tilley SL, Zeldin DC, Ledent C, Mustafa SJ “Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A receptor knockout mice” Am J Physiol Regul Integr Comp Physiol. 2012 Feb 15; 302(4):R400-8. doi: 10.1152/ajpregu.00481.2011. Epub 2011 Dec 7. PMID:22160543
- Ponnoth DS, Mustafa SJ “Adenosine receptors and vascular inflammation” Biochim Biophys Acta. 2011 May; 1808(5):1429-34. Epub 2010 Sep 9. Review. PMID:20832387 https://www.ncbi.nlm.nih.gov/pubmed/20832387
- Nayeem MA, Zeldin DC, Boegehold MA, Morisseau C, Marowsky A, Ponnoth DS, Roush KP, Falck JR “Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase” Am J Physiol Regul Integr Comp Physiol. 2010 Jul; 299(1):R325-33. Epub 2010 Apr 28. PMID:20427718 https://www.ncbi.nlm.nih.gov/pubmed/20427718
- Ponnoth DS, Nadeem A, Tilley S, Mustafa SJ “Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma.” Am J Physiol Heart Circ Physiol. 2010 Jul; 299(1):H81-7. Epub 2010 Apr 16. PMID:20400685 https://www.ncbi.nlm.nih.gov/pubmed/20400685
- Ponnoth DS, Sanjani MS, Ledent C, Roush K, Krahn T, Mustafa SJ “Absence of adenosine-mediated aortic relaxation in A(2A) adenosine receptor knockout mice.” Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1655-60. Epub 2009 Sep 11. PMID:19749167 https://www.ncbi.nlm.nih.gov/pubmed/19749167
- Nadeem A, Ponnoth DS, Ansari HR, Batchelor TP, Dey RD, Ledent C, Mustafa SJ "A2A AR deficiency leads to impaired tracheal relaxation via NADPH oxidase pathway in allergic mice." J Pharmacol Exp Ther. 2009 Jul;330(1):99-108. Epub 2009 Apr 24. PMID:19395654 https://www.ncbi.nlm.nih.gov/pubmed/19395654
- Nayeem MA, Ponnoth DS, Boegehold MA, Zeldin DC, Falck JR, Mustafa SJ “High salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases.” Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R567-74 PMID:19109366 https://www.ncbi.nlm.nih.gov/pubmed/19109366
- Nayeem MA, Poloyac SM, Falck JR, Zeldin DC, Ledent C, Ponnoth DS, Ansari HR, Mustafa SJ “Role of CYP epoxygenases in A2AAR-mediated relaxation using A2AAR-null and wild-type mice.” Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2068-78. PMID:18805895 https://www.ncbi.nlm.nih.gov/pubmed/18805895
- Ponnoth DS, Nadeem A, Mustafa SJ “Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma.” Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2158-65. PMID:18310516 https://www.ncbi.nlm.nih.gov/pubmed/18310516