Faculty & Research Interests

Faculty


Rutesh H. Dave, Ph.D.
Associate Professor and Division Director of Pharmaceutical Sciences
Rutesh.Dave@liu.edu
(718) 488-1660


Education

Ph.D., Long Island University, Brooklyn, NY
B.S. Pharm, K.L.E. College of Pharmacy, Belgaum, India





Short Biography

Dr. Dave joined Long Island University in 2008, before joining the college, Dr. Dave worked at Par pharmaceuticals and SigmaPharm as a senior scientist and group leader of R&D formulation and worked on various solid dosage form development from laboratory to scale-up. Dr. Dave started his laboratory at LIU with a dissolution apparatus and UV spectrophotometer and few chemicals. He started his laboratory with few master students and developed many joint projects with pharmaceutical industries and converted his laboratory into a full-fledged research laboratory. He served as a graduate program director for Industrial Pharmacy and Pharmacology before becoming the Division Director. Dr. Dave was also instrumental in opening the LIU-Natoli institute for Industrial Pharmacy Research and Development where scientists from academia, industry and governmental agencies can work to develop and solve problems related with solid dosage form. Dr. Dave also serves as a principal investigator of that institute. Dr. Dave is also the recipient of Newton award for his excellence in teaching and is also a recipient of the Founders award for his service to the college. Dr. Dave’s students have received various research awards at regional and national level. Dr. Dave has published extensively in national and international journals and is also reviewer and editorial boards of several scientific journals. His laboratory is divided into four research areas:

  1. Solubility enhancement using innovative approaches
  2. Powder characterization
  3. Generic and 505 (b) 2 development
  4. Developing oral strip formulation.

Research Synopsis

The majority of my research is divided into the areas mentioned above. Many drugs are developed every single day and one of the biggest challenge is to improve the solubility and permeability of the drugs. Solubility is biggest hindrance to many new molecules coming into the market. The focus of our research in this area is to understand how solubility can be improved using various techniques and theory. Powders are very crucial into developing a solid dosage form and our research focuses on understanding the intrinsic behavior of powders so that later on during the developmental work this does not become and issue. For the oral strip formulation, our laboratory focuses on new ways to incorporate drugs into a strip formulation. In many countries drinking water is an issue and if we can incorporate drugs into strip which does not require water that will help save lives of many people across the globe.


Selected Publications

  • Dudhat, S.M., C.N. Kettler, and R.H. Dave, To Study Capping or Lamination Tendency of Tablets Through Evaluation of Powder Rheological Properties and Tablet Mechanical Properties of Directly Compressible Blends. AAPS PharmSciTech, (Early online July 2016)
  • Dugar, R.P., B.Y. Gajera, and R.H. Dave, Fusion Method for Solubility and Dissolution Rate Enhancement of Ibuprofen Using Block Copolymer Poloxamer 407. AAPS PharmSciTech, (Early online Jan 2016).
  • Dugar, R.P., P. Gupta, and R.H. Dave, Effect of relative humidity on acetaminophen tablet properties prepared by different techniques using polyvinylpyrrolidine derivatives as binder. International Journal of Pharmaceutical Sciences and Research, Vol. 6 (11), pg. 4629-4638, 2015.
  • Jagia, M., M. Trivedi, and R.H. Dave, To Evaluate the Effect of Solvents and Different Relative Humidity Conditions on Thermal and Rheological Properties of Microcrystalline Cellulose 101 Using METHOCEL™ E15LV as a Binder. AAPS PharmSciTech, Vol.14 (4), pg. 995-1006, August 2016
  • Shah, D.A., S.B. Murdande, and R.H. Dave, A Review: Pharmaceutical and Pharmacokinetic Aspect of Nanocrystalline Suspensions. Journal of Pharmaceutical Sciences, Vol. 105 (1), pg. 10-24, 2016
  • Patel, A.A. and R.H. Dave, Development and characterization of innovative liquid salt based formulations of sparingly soluble drugs. International Journal of Pharmaceutical Sciences and Research, Vol. 6 (6), p. 2316-2327, 2015
  • Al-Nemrawi, N.K. and R.H. Dave, Effect of Formulation Variables on Poly (lactic-co-glycolic acid) Nanoparticle Properties: A Factorial Design Study. Journal of Pharmaceutical Sciences and Pharmacology, 2015. 2(1): p. 1-10.
  • Murdande, S.B., D.A. Shah, and R.H. Dave, Impact of nanosizing on solubility and dissolution rate of poorly soluble pharmaceuticals. Journal of Pharmaceutical Sciences, 2015. 104(6): p. 2094-2102.
  • Dugar, R.P. and R.H. Dave, To study the effects of solvent and relative humidity on rheological and thermal properties of microcrystalline cellulose granules using hydroxypropyl methylcellulose as binder. International Journal of Pharmaceutical Sciences and Research, 2014. 5(9): p. 3616.
  • Al-Nemrawi, N.K. and R.H. Dave, Formulation and characterization of acetaminophen nanoparticles in orally disintegrating films. Drug Delivery, 2016. 23(2): p. 540-549.
  • Chaudhari, S.P. and R.H. Dave, To prepare and characterize microcrystalline cellulose granules using water and isopropyl alcohol as granulating agents and determine its end-point by thermal and rheological tools. Drug Development and Industrial Pharmacy, 2014(0): p. 1-9.
  • Dave, R.H., D.A. Shah, and P.G. Patel, Development and evaluation of high loading oral dissolving film of aspirin and acetaminophen. Journal of Pharmaceutical Sciences and Pharmacology, 2014. 1(2): p. 112-122.
  • Patel, A.D., A. Agrawal, and R.H. Dave, Investigation of the effects of process variables on derived properties of spray dried solid-dispersions using polymer based response surface model and ensemble artificial neural network models. European Journal of Pharmaceutics and Biopharmaceutics, 2014. 86(3): p. 404-417.
  • Trivedi, M.R. and R.H. Dave, To study physical compatibility between dibasic calcium phosphate and cohesive actives using powder rheometer and thermal methods. Drug Development and Industrial Pharmacy, 2014. 40(12): p. 1585-1596.
  • Patel, A.D., A. Agrawal, and R.H. Dave, Development of polyvinylpyrrolidone‐based spray‐dried solid dispersions using response surface model and ensemble artificial neural network. Journal of Pharmaceutical Sciences, 2013. 102(6): p. 1847-1858.
  • Patel, V.I. and R.H. Dave, Evaluation of colloidal solid dispersions: physiochemical considerations and in vitro release profile. AAPS PharmSciTech, 2013. 14(2): p. 620-628.
  • Okoye, P., S.H. Wu, and R.H. Dave, To evaluate the effect of various magnesium stearate polymorphs using powder rheology and thermal analysis. Drug Development and Industrial Pharmacy, 2012. 38(12): p. 1470-1478.
  • Dave, R.H., S.H. Wu, and L.D. Contractor, To determine the end point of wet granulation by measuring powder energies and thermal properties. Drug Development and Industrial Pharmacy, 2012. 38(4): p. 439-446.
  • Dave, R.H., et al., To evaluate the effect of addition of an anionic surfactant on solid dispersion using model drug indomethacin. Drug Development and Industrial Pharmacy, 2012. 38(8): p. 930-939.
  • Matharu, A.S., et al., Evaluation of hydroxypropyl methylcellulose matrix systems as swellable gastro‐retentive drug delivery systems (GRDDS). Journal of Pharmaceutical Sciences, 2011. 100(1): p. 150-163.
  • Wu, Z., et al., Development of acetaminophen proline prodrug. Bioorganic & Medicinal Chemistry Letters, 2010. 20(13): p. 3851-3854.

CONTACT

LIU Pharmacy
John M. Pezzuto, A.B., Ph.D.
Dean